Malegra DXT Plus is used only when needed, therefore missed dosages are not relevant. Do not exceed the doctor’s recommended dose. Do not take a double dose. which is found mainly in the penis corpus cavernosum, resulting in prolonged penile erection. Dapoxetine acts by inhibiting the serotonin transporter resulting in increased serotonin output in both presynaptic and postsynaptic receptors, thereby significantly reducing premature ejaculation.Take this medication exactly as prescribed by the doctor. Follow all the usage instructions mentioned on the label This drug is made up of two drugs widely used in the treatment of premature ejaculation. Sildenafil acts by inhibiting a particular type 5 phosphodiesterase, which is found mainly in the penis corpus cavernosum, resulting in prolonged penile erection.