cliffordfosterr
231 posts
Sep 10, 2025
4:11 AM
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Malegra, a medication containing sildenafil citrate, is primarily metabolized in the liver. After oral administration, Malegra is absorbed into the bloodstream and undergoes metabolism mainly by the cytochrome P450 enzyme system, particularly CYP3A4 as the dominant pathway, with a smaller contribution from CYP2C9. These enzymes break sildenafil down into its primary active metabolite, N-desmethylsildenafil, which has about 50% of the potency of the parent compound. Both sildenafil and its metabolite are further processed before being excreted, mostly through the feces and to a lesser extent through the urine. Because Malegra depends on liver metabolism, patients with hepatic impairment or those taking strong CYP3A4 inhibitors (like ketoconazole or ritonavir) may experience higher drug levels, increasing the risk of side effects. This is why doctors carefully consider dosage adjustments and potential drug interactions when prescribing Malegra.
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