Roberttanser
307 posts
Oct 29, 2025
12:22 AM
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I couldn’t locate any reliable published data identifying exactly which hepatic enzymes metabolise Malegra FXT (a combination of sildenafil and possibly another agent). However, I can offer some educated inferences:
The sildenafil component of MALEGRA FXT is primarily metabolised by the CYP3A4 isoform of the cytochrome?P450 family.
Other CYP enzymes (such as CYP2C9, CYP2C19, CYP2D6) may play minor roles, but CYP3A4 is dominant.
For any additional active drug in the formulation, one should check its specific metabolism pathway.
Patients with impaired liver function may have reduced enzyme capacity, affecting clearance.
If you like, I can check for any recent pharmacokinetic studies specific to Malegra?FXT to identify the exact enzyme pathways.
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