kirazmattson
777 posts
Dec 03, 2025
2:08 AM
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Zudena 100 mg is taken orally, usually as a tablet. It can be taken with or without food, but a high-fat meal can delay absorption and reduce the speed at which it takes effect. Gastrointestinal Absorption: After swallowing, Sildenafil dissolves in the stomach and is absorbed primarily through the small intestine into the bloodstream. Bioavailability: The oral bioavailability of Sildenafil is roughly 40%, meaning about 40% of the ingested dose reaches systemic circulation in an active form. Onset of Action: Typically, effects are seen within 30–60 minutes after ingestion. Peak plasma concentration is reached in about 60 minutes under Zudena 100 Mg conditions. If taken with a fatty meal, peak levels may be delayed by an additional hour or more. Distribution: Sildenafil binds to plasma proteins (~96%) and is distributed throughout the body, including the penile tissue, where it inhibits the PDE5 enzyme to increase blood flow and facilitate erection. Metabolism: Sildenafil is metabolized in the liver by the CYP3A4 (major) and CYP2C9 (minor) enzyme pathways. Elimination: The drug’s metabolites are mostly excreted in feces (~80%) and some in urine (~13%). The half-life of Sildenafil is about 3–5 hours, which determines how long its effects last. Key Points for Absorption Efficiency: Avoid heavy meals immediately before taking Zudena to ensure faster onset. Alcohol and grapefruit juice can interfere with absorption and metabolism. Taking it with water ensures proper dissolution and faster absorption. If you want, I can also make a step-by-step timeline of how Zudena 100 mg works in the body, from ingestion to elimination, which makes it really easy to understand its onset, peak effect, and duration.
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