NeoDx
7 posts
Sep 28, 2026
8:53 AM
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The BCR-ABL Qualitative RT-PCR Detection Kit (MMM) by NeoDx is a multiplex real-time PCR assay designed for the precise detection and classification of Philadelphia chromosome–positive leukemias ($t(9;22)$ translocation).In a single-tube assay, this kit enables the simultaneous detection of Major (p210), Minor (p190), and Micro (p230) BCR-ABL transcripts, alongside the endogenous ABL1 internal control, using human whole blood EDTA or bone marrow aspirate samples.Key Features & Highlights:Single-Step Workflow: Integrated reverse transcription eliminates separate cDNA synthesis steps, reducing hands-on time.Rapid Diagnostic Results: Delivers accurate results in under 90 minutes.High Tolerance & Sensitivity: Powered by Takara MasterMix for superior inhibitor tolerance, high thermostability, and consistent reproducibility.Broad Instrument Compatibility: Runs seamlessly on standard real-time PCR systems supporting FAM, HEX/VIC, Texas Red/ROX, and Cy5 channels.Regulatory Approved: CDSCO approved for IVD use in professional diagnostic environments.Clinical Utility:Facilitates accurate baseline diagnostic subtyping for Chronic Myeloid Leukemia (CML), $Ph+$ Acute Lymphoblastic Leukemia (Ph+ ALL), and atypical myeloproliferative disorders to guide Tyrosine Kinase Inhibitor (TKI) therapy decisions.
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